his article examines Lewis Caerleon’s notebook, Cambridge, Univer- sity Library, MS Ee.3.61, composed between 1481 and 1484 and mainly copied by him. This volume of 192 folios contains mathematical, astronomical and astro- logical works. Amongst them are the drafts and notes of the physician- astronomer himself. This material includes computations, tables and treatises revealing an astronomical programme in which eclipses played a central role. This article attempts to provide a detailed account of the production and pur- pose of the notebook, and endeavours to situate this volume within Lewis Caer- leon’s scientific production and extant manuscripts. New evidence about the life of Lewis Caerleon and his manuscripts are also provided. An analysis of newly discovered evidence retained in the notebook suggests that Lewis Caerle- on’s eclipse writings are mainly based on the works of two little-known fif- teenth-century astronomers from Merton College, Oxford.